Orange hawkweed is known to form dense patches that begin in open, disturbed areas. In eastern Oregon, orange hawkweed is known as a rangeland weed. In the greater Portland area, it seems to find a similar home in turf and lawns.

It has persistent root systems which do not respond well to some herbicide treatments, making management of established populations difficult. Orange hawkweed infestations can lead to reduced plant and animal diversity as other species are choked out, as well as diminished agricultural value.

Orange hawkweed is primarily spread by fluffy seeds, although new plants are often formed by difficult-to-see above-ground runners. Using these two strategies, orange hawkweed is able to quickly fill in open spaces and resist management.